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Expert prediction

NFL Week 8: Bills vs. Panthers Preview, Odds, Picks (Oct 26)

  • Nikola Velickovic
  • Oct 21, 2025 at 5:43 AM EDT
  • Bills vs. Panthers odds favor Buffalo at -425.
  • Carolina Panthers have 3 wins in a row.
  • The Buffalo Bills lost back-to-back games.

We didn’t expect to see Carolina posting three in a row, and we most definitely haven’t anticipated the Bills losing back-to-back matches. Josh Allen and the guys are under pressure here, while the Panthers have great momentum ahead of this one.

How to Watch

  • When: Sunday, October 26, 1 pm ET
  • Where: Bank of America Stadium, Charlotte, North Carolina
  • How to Watch: FOX

Bills vs. Panthers Odds

TeamMoneylineSpreadTotals
Bills -425-7.545.5
Panthers+320+7.545.5

Game Preview

The Bills first lost to the Pats at home, then went to Atlanta, where the Falcons inflicted them with another loss, 24-14, showing that one of the top Super Bowl contenders is going through a crisis. A week off came at the right moment for them, but we’ll see if they used it in the right way.

Buffalo’s run defense is the second-worst in the NFL, allowing 156.3 rushing yards per game. Though the pass defense is the second-best, allowing just 167.2.

Panthers have 3 wins in a row, and they are currently the breakthrough in the NFL. Sure, the rivals weren’t that hard – Dolphins, Cowboys, and the most recent, Jets in New York. That one ended 13-6 in Carolina’s favor.

Bryce Young injured his ankle in New York, and he is still day-to-day, but veteran Andy Dalton is ready to fill in. RB Rico Dowdle had 79 rushing yards, while WR Xavier Legette caught 9 passes for 92 yards and the sole TD in the game. Special shoutout to the Panthers’ defense, who had 6 sacks and 11 QB hits.

Bills vs. Panthers Head to Head

After 8 meetings, the Bills lead the series 6-2.

Bills vs. Panthers Predictions

This one will be tough. We are leaning toward Under here, because the Bills’ previous few games ended like that, and also, because the Panthers’ defense showed its potential in the past few weeks.

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