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Expert prediction

NFL Week 3: Cowboys vs. Bears Preview, Odds, Picks (Sep 21)

  • Nikola Velickovic
  • Sep 17, 2025 at 5:21 AM EDT
  • Cowboys vs. Bears odds are even.
  • The total for this game is 49.5 points.
  • Both of Chicago’s games went Over.

The Bears’ defense has to be much better. They’ve allowed 79 points in the opening two rounds, and the next rival also knows how to get into a high-scoring mode.

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How to Watch

  • When: Sunday, September 21, 4:25 pm ET
  • Where: Soldier Field, Chicago, Illinois
  • How to Watch: FOX

Cowboys vs. Bears Odds

TeamMoneylineSpreadTotals
Cowboys-110Even49.5
Bears-110Even49.5

Game Preview

Dallas Cowboys beat the Giants after an OT, 40-37, getting their first triumph of the year. It was a good game in which the Cowboys got tested, yet replied each time. QB Dak Prescott had 361 passing yards for 2 touchdowns and a pick.

RB Javonte Williams had a good role, rushing for 97 yards and a touchdown. He also added 33 receiving yards, making this one a very good performance overall. Besides that, we have to mention WR CeeDee Lamb, who caught 112 passing yards.

Bears fans felt the Lions’ wrath as they were hammered in Detroit, 52-21. Their defense allowed 511 yards, while the offense had two turnovers. That’s bad, no matter the fact that the Lions are the most potent offensive team in the NFL.

QB Caleb Williams had two touchdowns and was picked once, and his favorite target was WR Rome Odunze, who caught both TD passes and finished with 128 receiving yards.

Cowboys vs. Bears Head to Head

The Dallas Cowboys won the last meeting in 2022, 49-29, and they lead the all-time series, 16-12.

Cowboys vs. Bears Predictions

We’ll need 50 points to make our bet a winning one here, and given the way these two teams play lately, we really think that’s achievable. Defenses aren’t the strongest parts of both the Cowboys and the Bears, which is why OVER is the final decision.

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