Skip to content

Expert prediction

College Football Gameday Picks: Best Straight-Up Predictions and Odds (Sep 26)

  • Keith McCarthy
  • Sep 25, 2026 at 11:17 PM EDT

Pick rationale

Analysis & key factors

  • The college football season continues with several key Week 4 clashes.
  • A matchup between #1 Texas and #14 Tennessee leads this week’s slate.
  • We’ll break down the top matchups for the best straight-up predictions.

The rankings continue to change as we enter Week 4 of the college football season. There are plenty of great odds and picks to bet on this week, so don’t miss our predictions for this week’s top-5 matchups straight-up.

Best Straight-Up College Football Picks

UCLA vs Maryland

UCLA opened the season 3-0, but should be feeling the effects of coast-to-coast travel in this game. Maryland holds up well with the Bruins in many statistical categories, and should be set up well to hand UCLA their first defeat of the season. Take the Terps in this one.

TCU vs UCF

In a battle of 2-1 Big-12 teams, TCU is slightly favored on the road. The Horned Frogs opened the season as a borderline top-25 team, and should be set up well to overwhelm UCF with talent in this game. Look for TCU to pull away early and not look back in a confident victory.

UConn vs Miami-OH

Miami-Ohio enters this game as the favorite after playing Cincinnati close. Their advantage is compounded by playing this one at home, but their offense is vulnerable and likely to fall short against UConn. Don’t expect a repeat of last week for the Redhawks, the Huskies should win here confidently.

Nebraska vs Michigan State

Nebraska is looking to improve to 4-0 in this game against Michigan State. It won’t be a breeze on the road, but the Cornhuskers are a borderline top-25 team and hold several notable advantages over the Spartans. Look for Nebraska to win this one by a considerably large margin.

James Madison vs Old Dominion

The Dukes have been the premier program in the G5/G6 since making the transition to the FBS level and are continuing it this season. Favored to win this game and climb to 4-0, James Madison should hold a notable advantage, despite being on the road. Take them to win this matchup.

Topics:

NCAAF

More Predictions

NCAAF Insight

FCS Picks: #3 Montana #13 Northern Arizona Odds & Prediction (Oct 10)

In this week’s FCS picks, we’ll break down the Montana vs Northern Arizona matchup, featuring a battle of top-15 teams. The Grizzlies enter as the favorite, despite being on the road. They will be aiming to improve to 39-15 against Northern Arizona all-time. Montana Looks to Keep Rolling Montana enters this game having historically dominated […]

Keith McCarthy 2 min read

NCAAF Insight

FCS Picks: #2 Tarleton State vs #8 Austin Peay Odds & Prediction (Oct 10)

In this week’s FCS picks, we’ll break down the Tarleton State vs Austin Peay matchup, featuring a battle of top-10 teams. They played a thriller last season in a 45-44 result, and are likely to hold another very competitive high-stakes matchup in this rematch. Tarleton State Eyes FCS Top Spot Tarleton State is one of […]

Keith McCarthy 2 min read

NCAAF Insight

NCAAF: #5 Ohio State vs #14 Iowa Preview, Odds, Picks (Oct 3)

In this week’s Ohio State vs Iowa matchup, the Buckeyes and Hawkeyes face off in an undefeated battle. Ohio State is heavily favored, despite being on the road. They opened the season at #1 in the country but have since fallen to #5, aiming to rise back up. Ohio State Seeks to Continue Rising Ohio […]

Keith McCarthy 2 min read

NCAAF Insight

NCAAF: #7 Alabama vs #16 Mississippi State Preview, Odds, Picks (Oct 3)

In this week’s Alabama vs Mississippi State matchup a pair of top SEC teams faces off in a top-20 matchup. The Crimson Tide are favored to win on the road but face a challenge against a rough Bulldogs team. The winner will rise to 5-0 and the top of the SEC. Alabama Seeking to Rise […]

Keith McCarthy 2 min read

NCAAF Insight

College Football Picks Gameday: Best ATS Predictions and Odds (Sep 26)

The rankings continue to change as we enter Week 4 of the college football season. There are plenty of great odds and picks to bet on this week, so don’t miss our predictions for this week’s top-5 matchups against-the-spread. Best ATS College Football Picks #1 Texas vs #14 Tennessee Texas has been rolling ever since […]

Keith McCarthy 2 min read