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Expert prediction

NCAAF: #17 Iowa vs #18 Michigan Preview, Odds, Picks (Sep 26)

  • Keith McCarthy
  • Sep 22, 2026 at 1:58 AM EDT

Pick rationale

Analysis & key factors

  • Iowa dominated Northern Iowa last week, defeating them by a score of 55-0.
  • Michigan took down UTEP 52-7, improving to 3-0 overall on the season.
  • These two teams last met on December 2, 2023, in a game that Michigan won 26-0.
  • Michigan Wolverines -5.5

Iowa and Michigan face off on Saturday in a B1G matchup between two top-20 teams. Michigan is favored to win at home but faces a tough challenge against a very stout Iowa defense.

Iowa Seeks B1G Upset Over Wolverines

Iowa faces their toughest test of the season yet against #18 Michigan, hoping to pull off the upset and enter the top-15. The Hawkeyes already have two shutouts in three games this season, and have allowed just 13 points in total. They’ll put their defensive chops to the test against a Wolverines offense that scored 52 points against UTEP last week. A win would also drastically improve Iowa’s chances of making a run for the Big-10 title.

Michigan Looks to Keep Climbing Rankings

Michigan enters this game against Iowa inside the top-20, after starting the season 3-0. A win over Oklahoma in Week 2 set the Wolverines up well to have a shot at returning to the CFP this season. This matchup against Iowa will be key in those chances, with a loss at home likely to affect them later on should they take one. Michigan will face a test against Iowa’s dominant defense, but has historically performed well against them.

#17 Iowa vs #18 Michigan NCAAF Pick

In this B1G battle, Michigan is favored to win thanks to their home-field advantage. Iowa’s defense will certainly test them and keep this one close, but expect the Wolverines to get what needs to be done to win and cover. The fans in the Big House should be roaring as Michigan improves to 4-0 in this game.

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