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Expert prediction

College Football Picks Gameday: Best ATS Predictions and Odds (Sep 26)

  • Keith McCarthy
  • Sep 25, 2026 at 11:05 PM EDT

Pick rationale

Analysis & key factors

  • The college football season continues with several key Week 4 clashes.
  • A matchup between #1 Texas and #14 Tennessee leads this week’s slate.
  • We’ll break down the top matchups for the best against-the-spread picks.

The rankings continue to change as we enter Week 4 of the college football season. There are plenty of great odds and picks to bet on this week, so don’t miss our predictions for this week’s top-5 matchups against-the-spread.

Best ATS College Football Picks

#1 Texas vs #14 Tennessee

Texas has been rolling ever since defeating Ohio State and overtaking the #1 spot in the rankings. Expect them to keep the momentum up against a strong, but likely not strong enough, Tennessee team. The Longhorns should win this one by a touchdown or two.

#4 Ole Miss vs #21 Florida

Ole Miss has looked dominant so far this season. Despite facing a top-25 team on the road, the Rebels should be favored by more than 3.5 points in this game. The Gators are capable but not in the same class of talent as of now. Ole Miss should win this one by more than enough to cover.

#17 Iowa vs #18 Michigan

Michigan is ranked a spot below Iowa but benefits from home-field advantage in this game. Expect the Big House to be rocking as the Wolverines fight to get back into CFP contention. Iowa’s defense will pose a test, but Michigan should win by enough to cover.

#20 Oregon vs #12 USC

It’s a bit surprising to see Oregon favored on the road against a USC team ranked eight spots higher. The Ducks barely escaped Boise State before losing to Oklahoma State, and their thumping of FCS Portland State isn’t enough to trust them yet. Lock in USC at home in this one.

#23 Texas A&M vs #10 LSU

LSU has been very strong so far this season, and is likely to win this matchup at home. That being said, the Aggies are also very capable and often play the Tigers close. Expect this game to finish as a one-score result, allowing Texas A&M to cover the spread on the road.

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