Expert prediction
NFL Week 4 Predictions: Best Bets, Odds & Upset Pick
Pick rationale
Analysis & key factors
NFL Week 4 action begins Thursday Night in Cleveland with an AFC North clash between the Pittsburgh Steelers and Cleveland Browns. You all know what that means, because games in this division are ruthless. As we like to say, NFL odds are ready, picks are ready and so are we
Sunday morning brings the NFL’s first London game at Tottenham Hotspur Stadium as the Indianapolis Colts meet the Washington Commanders. Later that day, the Rams visit the Eagles, and Sunday night is reserved for the Lions vs. Panthers matchup in Charlotte.
The week wraps up with Monday Night Football in New Orleans, where the Saints host the division rivals, the Atlanta Falcons.
Below is our complete breakdown of top betting angles, value picks, key fixture previews, and the full schedule for NFL Week 4.
Week 4 Best Bets & Top Value Angles
- Best Moneyline: Patriots vs. Bills -300
- Top Handicap Pick: Buffalo Bills -7
- Top Value Over/Under: Jacksonville Jaguars at Cincinnati Bengals 51.5 points
- Top Upset Pick: Cowboys against the Texans
Key Fixture Breakdown & Predictions
Pittsburgh Steelers at Cleveland Browns Prediction & Odds
Kickoff: Thursday, October 1 | 8:15 PM ET / 02:15 CET (Fri) | Huntington Bank Field, Cleveland, OH
Match Preview
Cleveland is on the rise. That’s what the record says, but we can’t agree because they beat two mediocre rivals solely on individual talent and opponents’ mistakes. Meanwhile, the Steelers are more consistent and are playing at home. Aaron Rodgers knows how to handle defenses like the Browns’, while on the other hand, Pittsburgh’s defense will be more than enough to disrupt Cleveland’s attack.
- Best Bet: Steelers -2.5
Los Angeles Chargers vs. Seattle Seahawks Prediction & Odds
Kickoff: Sunday, October 4 | 4:25 PM ET / 10:25 CET | Lumen Field, Seattle, Washington
Match Preview
Chargers are in massive trouble, and for the moment, they can’t control the situation. LAC travels to Seattle at the worst possible moment, with the Seahawks losing their first meeting of the year last weekend and Sam Darnold ready to get back into the rhythm after his injury. On top of all that, the Chargers have terrible offensive productivity, scoring only 14.7 points per game. So no need to say why we bet on the Super Bowl champions to be routine and win this one in front of their own fans.
- Best Bet: Seahawks -7
New England Patriots vs. Buffalo Bills Prediction & Odds
Kickoff: Sunday, October 4 | 1 PM ET / 7 CET | New Highmark Stadium, Orchard Park, New York
Match Preview
Both teams were after the top spot in the AFC East before the season started. But right now the Pats are on the downhill, unlike the steaming Bills who are undefeated after three weeks. Buffalo has the league’s best offense, averaging 33.7 points per game, while the Patriots score only 12 points per contest. It’s evident that New England’s quality of play has severely dropped from the previous year and that right now, they are nothing more than a mediocre unit.
- Best Bet: Bills -7
NFL Week 4 Upset Pick
Dallas Cowboys vs. Houston Texans Prediction & Odds
Kickoff: Sunday, October 4 | 1 PM ET / 7 CET | Reliant Stadium, Houston, Texas
Match Preview
Texas derby puts more pressure on the Texans, who are 0-3 right now. Dallas is 1-2 but has faced tougher rivals than Houston, which struggles on offense. To be more precise, CJ Stroud struggles and is in an obvious crisis. Because of that, and the fact that the Cowboys are extremely potent on offense, we are siding with the guests to use the Texans’ current problems and pressure to take a win on the road.
Best Upset Bet: Cowboys
Complete NFL Week 4 Schedule & Odds Table
| Date | Time (ET / CEST) | Fixture | Pick |
| Thu, Oct 1 | 8:15 PM ET / 02:15 CET (Fri) | Cleveland Browns at Pittsburgh Stelers | Steelers -2.5 |
| Sun, Oct 4 | 9:30 AM ET / 15:30 CET | Indianapolis Colts vs. Washington Commanders (London) | Colts |
| Sun, Oct 4 | 1:00 PM ET / 19:00 CET | Arizona Cardinals at New York Giants | Cardinals |
| Sun, Oct 4 | 1:00 PM ET / 19:00 CET | Dallas Cowboys at Houston Texans | Cowboys |
| Sun, Oct 4 | 1:00 PM ET / 19:00 CET | Green Bay Packers at Tampa Bay Buccaneers | Packers |
| Sun, Oct 4 | 1:00 PM ET / 19:00 CET | Jacksonville Jaguars at Cincinnati Bengals | Bengals |
| Sun, Oct 4 | 1:00 PM ET / 19:00 CET | Los Angeles Rams at Philadelphia Eagles | Over 44.5 |
| Sun, Oct 4 | 1:00 PM ET / 19:00 CET | New England Patriots at Buffalo Bills | Bills -7 |
| Sun, Oct 4 | 1:00 PM ET / 19:00 CET | New York Jets at Chicago Bears | Bears -3.5 |
| Sun, Oct 4 | 1:00 PM ET / 19:00 CET | Tennessee Titans at Baltimore Ravens | Ravens -11.5 |
| Sun, Oct 4 | 4:05 PM ET / 22:05 CET | Miami Dolphins at Minnesota Vikings | Dolphins +10 |
| Sun, Oct 4 | 4:25 PM ET / 22:25 CET | Denver Broncos at San Francisco 49ers | 49ers -3 |
| Sun, Oct 4 | 4:25 PM ET / 22:25 CET | Kansas City Chiefs at Las Vegas Raiders | Raiders +4.5 |
| Sun, Oct 4 | 4:25 PM ET / 22:25 CET | Los Angeles Chargers at Seattle Seahawks | Seahawks -7 |
| Sun, Oct 4 | 8:20 PM ET / 02:20 CET (Mon) | Detroit Lions at Carolina Panthers | Lions -3.5 |
| Mon, Oct 5 | 8:15 PM ET / 02:15 CET (Tue) | Atlanta Falcons at New Orleans Saints | Over 48.5 |
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